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Post-doctoral Fellow in Drug Delivery, Nanomedicine & Advanced Therapeutics at the Department of Pharmacology and Pharmacy (several posts)

The University of Hong Kong

Apply now Ref.: 523977
Work type: Full-time
Department: Department of Pharmacology and Pharmacy (21300)
Categories: Senior Research Staff & Post-doctoral Fellow
Hong Kong

Post-doctoral Fellow in Drug Delivery, Nanomedicine & Advanced Therapeutics at the Department of Pharmacology and Pharmacy (several posts) (Ref.: 523977) 

We now invite applicants to join the Science, technology, engineering, and mathematics Lab of Drug Delivery, Nanomedicine & Advanced Therapeutics at the Department of Pharmacology and Pharmacy, LKS Faculty of Medicine. We are looking to recruit a number of highly motivated postdoctoral fellows, PhD students, a lab technician and a research officer.

The aim of our lab is to use nanotechnology to better understand, diagnose and treat diseases with particular interests in cancer and neurodegenerative diseases. We are a highly collaborative and multidisciplinary lab eager to create an impact on people’s lives taking research a step beyond the lab.  Research projects we are looking to pursue are in the areas of extracellular vesicles & cell therapy, immunotherapy, nucleic acids therapeutics for brain cancer and neurodegenerative diseases.

 

Duties and Responsibilities:

  • Design and develop small molecules, nucleic acids and peptide therapeutics.
  • Design, prepare and characterize nanoparticles.
  • Employ state-of-the-art techniques to assess the physicochemical properties of nanoparticles, ensuring their stability, drug release kinetics, encapsulation efficiency and electron microscopy imaging.
  • Integrate innovative approaches to enhance the specificity and efficiency of advanced therapeutics, with a particular emphasis on addressing challenges related to tissue penetration and targeted delivery.
  • Conduct cell culture studies using cell lines, primary cultures and/or patients' tissues for efficacy evaluation.
  • Conduct in vivo studies, including administration of nanoparticles, monitoring fate, therapeutic response, and assessing the impact on disease progression.
  • Develop relevant disease models to assess therapeutic efficacy of a specific treatment.
  • Demonstrate understanding of the disease pathology for better design of advanced therapeutics.
  • Coordinate with clinical collaborators to obtain ethical approvals and obtaining human tissue samples for subsequent studies.
  • Engage in collaborative projects both internally and externally.
  • Periodically report progress to PI, co-investigators, project collaborators, and project funder.
  • Initiate and contribute to grant writing activities.
  • Write study-specific procedures for analytical methods, protocols, and reports and provide training on processes and equipment.
  • Supervise and co-supervise undergraduate and postgraduate students.
  • Disseminate research findings through the preparation of research articles and presentations at international conferences.
  • Foster an agile and friendly working environment within the research group.

 

Requirements:

Education and Expertise:

  • Ph.D. in Pharmaceutical Sciences, Pharmacology, Biology, Molecular Biology, Biochemistry, Immunology, Bioengineering, Chemistry, Data Science or related fields.
  • Post-doctorate experience preferred.
  • Proven track record in conducting high-quality biological or chemical research.
  • Demonstrated history of writing reports and scientific articles based on research results.

 

Research Skills:

  • Strong background in various research areas including pre-clinical studies, image-guided delivery, nucleic acid therapeutics, targeting and therapeutic aptamers/peptides, immunotherapy, RNA biology, nose-to-brain delivery, blood brain barrier targeting, nanoparticle formulation, peptide therapeutics, T cells therapy, extracellular vesicles, cancer vaccines, brain cancer, motor neuron disease, protein corona, hydrogels, and gene therapy/editing.
  • Hands-on experience in advanced cell culture techniques and in vivo models.
  • Proficiency in various cell and molecular biology experimentation techniques like PCR, gels, Western blotting, Immunohistochemistry, ELISA and flow cytometry, immune profiling.
  • Experience in bioconjugations.

 

Desirable Skills:

  • Highly desirable skills include various in-vivo tracking modalities and imaging techniques for monitoring drug delivery dynamics.
  • Additional advantageous skills involve working with patient tissue handling and culturing, surgical implantation of brain cancer, cryo-electron microscopy, transcriptome, proteome, single cell sequencing and bioinformatics, iPSC derived cells, tissue organoids and/or tissue slices, analytical techniques e.g. LC-MS, liquid scintillation, HPLC, MS, NMR.

 

Administrative and Collaborative Skills:

  • Ability to manage a research programme financially and administratively under the guidance of the Principal Investigator.
  • Ability to work independently with excellent problem-solving skills, collaborate within a team, and supervise students.
  • High attention to detail in experimental design and execution with a willingness to adapt to new procedures and undergo further training as necessary.

 

Language and Technical Competence:

  • Excellent command of written and spoken English.
  • Capable of writing grants and contributing to additional funding acquisition.
  • Proficient in IT skills for efficient data management and communication within the research programme.

 

What We Offer

The appointment will commence as soon as possible on a temporary basis for 1 year, with the possibility of renewal up to 3 years subjected to satisfactory performance and funding availability. A highly competitive salary commensurate with qualifications and experience will be offered. Other benefits include annual leave, medical benefits and free access to on-campus gyms and libraries.

 

How to Apply

The University only accepts online application for the above post(s). Applicants should apply online at the University’s Careers site (https://jobs.hku.hk) and upload an up-to-date C.V. Review of applications will start as soon as possible and continue until April 30, 2024, or until the post(s) is/are filled, whichever is earlier.

 

 

The University is an equal opportunities employer and
is committed to equality, ethics, inclusivity, diversity and transparency

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